{"id":8749,"date":"2023-04-25T13:10:54","date_gmt":"2023-04-25T10:10:54","guid":{"rendered":"https:\/\/pell.bio\/?p=8749"},"modified":"2023-04-25T13:18:14","modified_gmt":"2023-04-25T10:18:14","slug":"probiotics-and-phytocannabinoids-a-winning-combination-for-improving-gut-health","status":"publish","type":"post","link":"https:\/\/pell.bio\/en\/probiotics-and-phytocannabinoids-a-winning-combination-for-improving-gut-health\/","title":{"rendered":"Probiotics and Phytocannabinoids \u2013 A Winning Combination for Improving Gut Health"},"content":{"rendered":"\n<p><strong>Cannabinoids<\/strong> (via the endocannabinoid system) <strong>affect our gut, its microbiome, and the rest of the human body.<\/strong> Through the \u2018microbiome-gut-brain axis\u2019 and other pathways, phytocannabinoids (plant-derived cannabinoids) can bring about positive changes throughout the whole body, helping us deal with everything from low mood to <a href=\"https:\/\/pell.bio\/en\/anna-autoimmune-disease\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"text-decoration: underline;\">autoimmune problems<\/span><\/a> like inflammatory bowel disease.<\/p>\n\n\n\n<p>What about when things don\u2019t immediately improve, though? What can or should be done when phytocannabinoids do not bring the quick relief we\u2019re hoping for? Of course, <strong>as with any long-term solution, phytocannabinoids will always require patience and consistency from the user to bring out their full suite of benefits.<\/strong> That being said, there are certainly some factors that can delay the process.<\/p>\n\n\n\n<p>Today, P\u0112LL looks at one such reason why phytocannabinoids may take longer than usual to begin working fully \u2013 a common gut issue called<strong> dysbiosis.<\/strong> We\u2019ll delve right into what this condition means for cannabinoid absorption and the body\u2019s wider health, as well as exploring <strong>a secret weapon to restoring your gut health \u2013 probiotics!<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Dysbiosis<\/h4>\n\n\n\n<p>Dysbiosis can be defined as an imbalance or disruption in the gut\u2019s microbiome. It may be characterised by an increase or decrease in the size of the gut\u2019s microbial community, or variations in the proportions of different types and species of microbes. Dysbiosis can be caused by a wide range of factors both internal and external, including illness, genetic predisposition, diet, antibiotics, and pollution.<\/p>\n\n\n\n<p><strong>Dysbiosis can impact basically all aspects of the human body \u2013 from mood fluctuations to digestion of food to immune response<\/strong> (ability to deal with viruses, toxins and other external violent intruders). For example, dysbiosis can affect the activity of beta-glucuronidase, an enzyme created by the body and found in the gut, which helps break down substances such as drugs, toxins. And <strong>dysbiosis affects the number of cannabinoid receptors in our body<\/strong> which is low when the gut microbiome is in bad shape, thus the poor absorption of the cannabinoids that you take in \u2013 they just don\u00b4t have anywhere to bind to.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Probiotics \u2013 what are they and how can they help?<\/h4>\n\n\n\n<p>There is evidence to suggest that <strong>phytocannabinoids can be used to address dysbiosis and restore gut homeostasis <\/strong>(balance in the gut microbiome composition, as it should be). But as dysbiosis can affect the uptake of cannabinoids in our guts in the first place, the process of re-balancing the gut microbiome may take longer than we\u2019d like if left to this alone. That\u2019s where probiotics come in.<\/p>\n\n\n\n<p><strong>Probiotics are live microorganisms that can be introduced to the gut microbiome to help redress dysbiosis<\/strong> (by re-populating or re-balancing microbial communities) or prevent an imbalance from occurring in the first place. Probiotics have shown to effectively quicken the process of the cannabinoid receptor formulation in the gut and body in general. This means that you will achieve the absorption of the phytocannabinoids quicker, the absorption will be better, and you will need to use less cannabinoids to achieve the same results.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">As a conclusion<\/h4>\n\n\n\n<p>So in conclusion we can say that <strong>in order to increase the level of bioavailability or absorption of cannabinoid products in your body and enhance their functionality you should support your body and more specifically the microbiome with probiotics.<\/strong> These can be found in abundance in <strong>fermented foods and drinks<\/strong> but also in <strong>special capsulated products.<\/strong> What will also happen is that your body\u00b4s own endocannabinoid system will be in a better shape and that in turn keeps your other bodily systems in healthy balance.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">References<\/h6>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Al-Ghezi, Z. Z., Busbee, P. B., Alghetaa, H., Nagarkatti, P. S., &amp; Nagarkatti, M. (2019). Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome. Brain, behavior, and immunity, 82, 25\u201335. https:\/\/doi.org\/10.1016\/j.bbi.2019.07.028<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Bailey, M. J., Naik, N. N., Wild, L. E., Patterson, W. B., &amp; Alderete, T. L. (2020). Exposure to air pollutants and the gut microbiota: a potential link between exposure, obesity, and type 2 diabetes. Gut microbes, 11(5), 1188\u20131202. https:\/\/doi.org\/10.1080\/19490976.2020.1749754<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., &amp; Schippa, S. (2018). Rebuilding the Gut Microbiota Ecosystem. International journal of environmental research and public health, 15(8), 1679. https:\/\/doi.org\/10.3390\/ijerph15081679<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Hrncir T. (2022). Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms, 10(3), 578. https:\/\/doi.org\/10.3390\/microorganisms10030578<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Messer, J. S., Chang, E. B. (2018). Edited by Said, H. M. Chapter 36 &#8211; Microbial Physiology of the Digestive Tract and Its Role in Inflammatory Bowel Diseases. Physiology of the Gastrointestinal Tract. 6th ed. Academic Press. 95-810. ISBN: 9780128099544. https:\/\/doi.org\/10.1016\/B978-0-12-809954-4.00036-0.<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Schiano Moriello, A., Di Marzo, V., &amp; Petrosino, S. (2022). Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint. Animals: an open access journal from MDPI, 12(3), 348. https:\/\/doi.org\/10.3390\/ani12030348<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Wang, F., &amp; Roy, S. (2017). Gut Homeostasis, Microbial Dysbiosis, and Opioids. Toxicologic pathology, 45(1), 150\u2013156. https:\/\/doi.org\/10.1177\/0192623316679898<\/li>\n<\/ul>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li>Wang, X., Zhang, P., &amp; Zhang, X. (2021). Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity.&nbsp;Molecules (Basel, Switzerland),&nbsp;26(19), 6076. https:\/\/doi.org\/10.3390\/molecules26196076<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Cannabinoids (via the endocannabinoid system) affect our gut, its microbiome, and the rest of the human body. Through the \u2018microbiome-gut-brain axis\u2019 and other pathways, phytocannabinoids (plant-derived cannabinoids) can bring about positive changes throughout the whole body, helping us deal with everything from low mood to autoimmune problems like inflammatory bowel disease. What about when things [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8753,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[173],"tags":[357,359,350,358,356],"class_list":["post-8749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pellcares-2","tag-dysbiosis","tag-gut-health","tag-microbiome","tag-phytocannabinoids","tag-probiotics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Probiotics and Phytocannabinoids \u2013 A Winning Combination for Improving Gut Health -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pell.bio\/en\/probiotics-and-phytocannabinoids-a-winning-combination-for-improving-gut-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Probiotics and Phytocannabinoids \u2013 A Winning Combination for Improving Gut Health -\" \/>\n<meta property=\"og:description\" content=\"Cannabinoids (via the endocannabinoid system) affect our gut, its microbiome, and the rest of the human body. Through the \u2018microbiome-gut-brain axis\u2019 and other pathways, phytocannabinoids (plant-derived cannabinoids) can bring about positive changes throughout the whole body, helping us deal with everything from low mood to autoimmune problems like inflammatory bowel disease. What about when things [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pell.bio\/en\/probiotics-and-phytocannabinoids-a-winning-combination-for-improving-gut-health\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-25T10:10:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-25T10:18:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pell.bio\/wp-content\/uploads\/2023\/04\/Probiotics_phytocannabinoids_PELL_blog-1024x768.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ago Siiner\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ago Siiner\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta 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